The Role of Probiotics in HIV Patients With Immunological Non-Responder
Status:
Completed
Trial end date:
2018-12-27
Target enrollment:
Participant gender:
Summary
This study will address HIV patients who are on antiretroviral treatment (ART) and
experiencing immunological failure. The cause of immunological failure in HIV patients could
be due to several factors such as age, gender, Cluster of Differentiation (CD4)+ count before
started treatment and some inflammation in the gut. The C-C Chemokine Receptor 5 (CCR5)
receptor on T lymphocyte CD4+ are abundantly found in the gut and attacked by HIV virus
during acute infection causing irreversible damage.
The disruption of gut integrity and chronic inflammation further causing translocation of
bacteria in gut lumen to the blood. Thus resulting persistent low CD4+ or immunological
failure.
This evaluation plan is designed to establish the role of investigation product (probiotics)
to improve gut inflammation in HIV patients.