Overview

The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients

Status:
Completed
Trial end date:
2019-02-01
Target enrollment:
0
Participant gender:
All
Summary
The overall aim of this study is to examine the role of mitochondrial respiration in human diabetic tissue before and after ischemia. Furthermore we will examine the ability of ischemic preconditioning (IPC) to preserve the mitochondrial function and hemodynamic performance of both non-diabetic and diabetic fibers after ischemia. To increase our understanding on the metabolic changes during ischemia in both non-diabetic and diabetic tissue we will use Dimethyl Malonate and examine the impact of this blockade on post-ischemic mitochondrial respiration.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Aarhus
Criteria
Inclusion Criteria:

- Patients undergoing CABG or other surgery where extracorporal circulation will be
used.

Exclusion Criteria:

- raise in ischemic markers within 4 weeks

- ejection fraction <30

- Atrial fibrilation

- Oral opioid treatment