The Role of Methycobalamin in Early Dementia Patients With Vitamin B12 Deficiency and Hyperhomocysteinaemia.

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Patients who fit the inclusion criteria are admitted into the study. They are given 3 IV injection of MBL in the first week and one tablet three times a day for 16 weeks.

• Phase: Phase 4

Details

• Lead Sponsor: Eisai Co., Ltd.

Criteria

Inclusion:

• Patients with Dementia

• Serum B12 < 200 pmol/l

• Serum Homocysteine level > 11.0 micro mol/L

Exclusion:

Significant communication problems

• deafness, dysarthria, dysphasia etc.

• unstable DM or hypertension

• alcohol abuse

• co-existing diseases which may affect cognition e.g. cognitive cardiac failure, respiratory failure

• folate < 10 g/dl

• haemoglobin concentration < 10g/d

• abnormal thyroid function test or VDRL