The Role of Metformin and Colesevelam in Human GLP-1 Secretion

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Our primary hypothesis is that bile acid sequestrant colesevelam and the antidiabetic drug metformin potentiates the secretion of the gut hormone glucagon-like peptide 1 (GLP-1).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Treatments: Colesevelam Hydrochloride; Metformin

Criteria

Inclusion Criteria:

• Normal hemoglobin

• BMI > 23kg/m2

• HbA1c <9 %

• Informed concent

Exclusion Criteria:

• Liver disease ( aspartate aminotransferase/alanine aminotransferase >2 × reference value)

• Chronic intestinal disease

• History of liver and / or gallbladder disease

• Nephropathy (se-creatinine >110 µM and / or albuminuria)

• Insulin or GLP-1-based antidiabetic treatment

• History of cholecystectomy or surgical resection of bowel segment

• BMI <23kg/m2 or BMI >35 kg/m2

• Pregnancy