Overview

The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition

Status:
Recruiting
Trial end date:
2021-09-10
Target enrollment:
0
Participant gender:
All
Summary
The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain inflammation, and (3) cognitive benefit from surgery. This project will uncover links between inflamed carotid plaque and downstream brain inflammation. The invesigators will also determine carotid plaque imaging features predicting cognitive benefit from carotid surgery.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Scott Mcnally
Collaborator:
American Heart Association
Treatments:
Flutemetamol
Criteria
Inclusion Criteria:

• Patients ≥18 years old and plans for carotid endarterectomy.

Exclusion Criteria:

- Patients with carotid occlusion will be excluded, due to one carotid contributing to
both right and left brain blood supply.

- Other known sources of cardioembolism, including atrial fibrillation, mechanical heart
valve, left atrial or ventricular thrombus or intracardiac mass, endocarditis, EF <30%

- Known stroke mimics including multiple sclerosis or brain tumor

- MRI contraindications per ACR guidelines, including patients with pacemakers, renal
failure with eGFR<30 ml/min/1.73m2, and contrast allergy

- [18F]Flutemetamol contraindications per manufacturer guidelines, including patients
with prior reactions

- Known stage IV malignancy

- Pregnancy