Overview

The Role of Ketamine and Dexmedetomidine in Opioid-Sparing Analgesia

Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
0
Participant gender:
All
Summary
Optimal multimodal opioid-sparing analgesic technique is considered as one of the most important Enhanced recovery pathways (ERPs) or enhanced recovery after surgery (ERAS) interventions that mitigate the undesirable effects of surgical stress response. Implementation of ERP has been shown to reduce postoperative complications and shorten the hospital LOS.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Fayoum University Hospital
Treatments:
Dexmedetomidine
Ketamine
Criteria
Inclusion Criteria:

- Age 18 - 65 years

- Ejection fraction (EF) > 35%

- Elective isolated CABG

- Valve surgery, Atrial septal defect (ASD) closure

- Cross clamp time ≤ 90 min

- Cardiopulmonary bypass time ≤ 120 min.

Exclusion Criteria:

- Poor left ventricular function with intra-aortic balloon pump support

- Recent myocardial infarction (last seven days)

- Combined procedure (i.e., CABG + other heart/vascular procedure)

- Emergency surgery, and Redo surgery,Hepatic or renal failure, creatinine >1.5 -History
of neurological disorders or convulsions