The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
Status:
Suspended
Trial end date:
2027-04-30
Target enrollment:
Participant gender:
Summary
It is believed that important brain centers send signals through the vagus nerve to the liver
to suppress the amount of glucose (sugar) that gets produced. People who have received liver
transplants have had their vagus nerve cut during transplantation, and many of these
individuals have diabetes at one year post-transplant. The goals of this study are: to see
whether metabolic control centers in the brain can still be activated normally with the
medication diazoxide in patients who have had a liver transplant, and to understand whether
disrupting the vagus nerve would result in excess glucose being produced by the liver (ie. a
potential mechanism for why these patients develop diabetes).
Phase:
Phase 2
Details
Lead Sponsor:
Albert Einstein College of Medicine Albert Einstein College of Medicine, Inc.