The Role of HNKs in the Antidepressant Effect of Ketamine
Status:
Terminated
Trial end date:
2020-07-02
Target enrollment:
Participant gender:
Summary
The objective of the proposed study is to examine the relationship between serum
concentrations of HNK and changes in the Hamilton Depression Rating Scale (HDRS), Beck
Depression Inventory (BDI), and the Profile of Mood States (POMS), as well as
glutamatergic/GABAergic response. To achieve these aims the investigators propose a
double-blind, uncontrolled (no placebo, no healthy control subjects) study with several
different doses of ketamine. The investigators will conduct MRI scans to measure Glu and GABA
before and during the ketamine treatment.