Scientists have discovered a number of hormones that control our feelings of hunger and
fullness. One particular hormone, called GLP-1, has been associated with feelings of hunger
and fullness. The overall purpose of this study is to look more closely at how GLP-1 changes
these feelings and to observe how these hormones affect the brain's function. To do this,
volunteers will be asked to come to the clinic for a screening visit, and 2 study visits.
This is an outpatient study with a screening visit which will last about an hour and the two
subsequent study visits for about 3 hours each. During the study, patients will receive a
drug that blocks the effect of a hormone made in the gut. We will take a series of blood
samples to measure hormones and use functional magnetic resonance imaging (MRI) to take
pictures of the brain. Understanding the action of these hormones in the brain may eventually
lead to new ways to help people avoid obesity or lose weight.