The Role of Estrogen in the Neurobiology of Eating Disorders
Status:
Recruiting
Trial end date:
2023-09-30
Target enrollment:
Participant gender:
Summary
This is a randomized, double blind, placebo-controlled study of the effects of transdermal
estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder
pathology in hypoestrogenemic female adolescents and young adults (ages 14-35 years) with an
eating disorder characterized by extreme dietary restriction and/or excessive exercise.
Subjects will be randomized 1:1 to 12 weeks of transdermal estradiol with cyclic progesterone
or placebo patches and cyclic placebo pills. Study visits include a screening visit to
determine eligibility and visits at baseline, 8 weeks, and 12 weeks. Study procedures
comprise behavioral, neuroimaging, and endocrine assessments.