The Role of Endothelin in the Supine Hypertension of Autonomic Failure
Status:
Withdrawn
Trial end date:
2021-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to test the hypothesis that endothelin plays a role in the
pathogenesis of supine hypertension in pure autonomic failure by increasing vascular
resistance. To gauge its contribution to blood pressure regulation, pure autonomic failure
and multiple system atrophy patients with supine hypertension will undergo a medication
testing with the endothelin blocker, BQ123. We will compare the hemodynamic effects between
PAF and MSA patients. Our primary endpoint will be the decrease in blood pressure during the
administration of this compound.