The Role of Endocannabinoids in Insulin Production and Action
Status:
Completed
Trial end date:
2014-10-06
Target enrollment:
Participant gender:
Summary
Background:
- The endocannabinoid system is involved in different body functions and processes. It helps
regulate appetite and mood, and sends signals to the nervous system. It may also be involved
in how the body produces insulin during digestion. Researchers want to test two drugs that
work on the endocannabinoid system: nabilone and CP-945,598. These drugs may be able to
affect insulin levels in the blood. This information may suggest possible new treatments for
people with diabetes.
Objectives:
- To study how the endocannabinoid system is involved in insulin production and action.
Eligibility:
- Healthy men between 21 and 55 years of age.
Design:
- Participants will be screened with a physical exam and medical history. They will
provide blood and urine samples. They will also have imaging studies to test their brain
responses, especially to food-related cues. Some participants will also have a study
visit to test their insulin resistance levels.
- Participants will have four separate study visits 6 weeks apart. They will keep a food
diary before each visit. At each visit, they will have one of the following combinations
of drugs:
- Double placebo
- Placebo and nabilone
- Placebo and low dose of CP-945,598
- Placebo and high dose of CP-945,598.
- Participants will have follow-up visits 1 week after each study visit. Blood samples
will be taken.