The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients
Status:
Completed
Trial end date:
2011-12-09
Target enrollment:
Participant gender:
Summary
This study evaluates the efficacy of sleep deprivation treatment in accelerating
antidepressant responses when administered during the first week of medications and
augmenting a sustained response with chronobiological interventions. Sleep deprivation and
chronobiological augmentation may offer a rapid and sustained antidepressant response in mood
disorder patients treated with medication, sleep deprivation, bright light therapy and sleep
phase advance compared with medication only. The chronobiological treatment is rapid,
non-invasive and has few side effects and could be of significant clinical benefit.