The Role of Dendritic Cells in Hepatitis C Infection

• Status: Completed
• Trial end date: 2004-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The role of the dendritic cells, the most potent antigen presenting cells, in the establishment of chronic hepatitis C is not established. The study aims to define whether the dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the antiviral immune response they generate. The hypothesis is explored by investigating a group of patients prior to and after the initiation of standard treatment for hepatitis C with pegylated Interferon and Ribavirin.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University College, London
• Collaborator: Schering-Plough
• Treatments: Ribavirin

Criteria

Inclusion Criteria:

• anti-HCV positive

• HCV RNA positive

Exclusion Criteria:

• contraindications for antiviral treatment

• concurrent chronic viral infections