The Role of Cathepsin X in Infection With the Helicobacter Pylori
Status:
Unknown status
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of
infection as well as the success of antibiotic eradication of the bacteria. The investigators
want to demonstrate the importance of cathepsin X (CTSX), a cysteine protease, for the Hp
eradication success. The diversity of the innate immune response to H. pylori antigens
leading to either successful eradication of the infection or maintenance of chronic
inflammation is connected to CTSX. The aim of this study is to determine whether H. pylori
suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the
individuals that are not capable of eradicating the infection, opposite to H pylori in
patients with successful H pylori eradication . The investigators also investigate the
possibility whether strain-dependent differences in H. pylori lipopolysaccharide (LPS)
influence the CTSX expression and cytokine secretion.