Overview

The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

Status:
Recruiting
Trial end date:
2024-09-01
Target enrollment:
0
Participant gender:
All
Summary
Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve the healing of skin grafts and reduce the risk of infections after surgery in these patients. It is known that antibiotics, like all medications, have side-effects although these are rare. This research study is designed to show us whether antibiotics improve wound healing or not, so that we may determine if we should continue using antibiotics even if they have side-effects in some patients. Our hypothesis is that patients treated with post-operative, systemic antibiotics will demonstrate a statistically significant improvement in the survival of their facial full thickness skin grafts compared to patients who are not treated with systemic antibiotics.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Michigan
Treatments:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Cephalexin
Clindamycin
Penicillins
Criteria
Inclusion Criteria:

- all adult patients with a nasal or facial skin/soft tissue defect requiring
reconstruction limited to or including a full-thickness skin graft

Exclusion Criteria:

- current or recent (within one week of surgery) systemic antibiotic use, intolerance to
both clindamycin and cephalexin, discovery of a persistent cutaneous malignancy at the
site of the defect following the reconstructive procedure and previous reconstruction
at the site of the skin/soft-tissue defect.