The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Hypertensive patients often show an exaggerated rise in blood pressure during exercise
through overactivity of the exercise pressor reflex. An increasing body of evidence suggests
a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We
hypothesize that this effect of aldosterone is mediated by its direct action on the central
nervous system and that administration of mineralocorticoid receptor antagonists constitute
an effective treatment for EPR overactivity in hypertension, independent of reductions in
resting BP.