The Role of 5-alpha Reductase in Mediating Testosterone Actions
Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
Participant gender:
Summary
In normal men, the male hormone testosterone affects a number of things in the body including
muscle function and sexual function. An enzyme in the body called 5-alpha reductase converts
testosterone into another form called dihydrotestosterone (DHT) which has slightly different
effects. The purpose of this study is to find out how different amounts of the two different
forms of testosterone affect muscle function and sexual function in healthy young men like
you. This will be done by giving the men participating in the study different combinations of
hormone-related medication for 20 weeks and making measurements before, during and after the
medications to look for changes in lean body tissue, muscle size, muscle strength and leg
power, as well as sexual function and sexual activity in all participants.
Phase:
Phase 4
Details
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)