The Response To Ajmaline Provocation in Healthy Subjects

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes. Participants will the undergo detailed imaging with cardiac magnetic resonance imaging and deep genotyping to identify structural or genetic variants which might dictate the electrocardiographic patterns at rest and with sodium channel provocation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: St George's, University of London
• Treatments: Ajmaline; Lorajmine

Criteria

Inclusion Criteria:

• Asymptomatic healthy Volunteers

Exclusion Criteria:

• • Any prior cardiovascular illness

• Previous cardiac symptoms.

• History of unexplained syncope

• Any family history of proven sudden cardiac death or unexplained sudden death either in adulthood or infancy.

• Those unable to provide a two generation family history

• Abnormal resting ECG

• Any contraindications to cardiac magnetic resonance imaging

• Pregnant or breastfeeding women

• Intercurrent use of any medication known to be contraindicated in Brugada Syndrome