The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate whether commonly used blood pressure medications called "ACE inhibitors" can lower parathyroid hormone.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Captopril; Hormones; Lisinopril

Criteria

Inclusion Criteria:

• Healthy subjects with with no medical problems (n=15) and individuals with primary hyperparathyroidism (n=30)

• normal blood pressure or stage 1 hypertension that is either untreated, or adequately treated with a single anti-hypertensive medication.

• Age >18 years and <80 years

• Estimated GFR > 60ml/min

Exclusion Criteria:

• Chronic Kidney Disease or eGFR<60

• Stage 2 or Stage 3 hypertension or the use of more than 1 antihypertensive drug

• Type 2 Diabetes Mellitus that is not controlled by diet or Metformin alone or with a Hemoglobin A1c >7.5%

• History of liver failure

• History of heart failure

• The use of typical or atypical antipsychotic medications or lithium.

• Chronic inflammatory conditions (such as inflammatory bowel disease or arthritis) that are treated with prescribed doses of NSAIDs or glucocorticoids

• The use of prescribed doses of potassium supplements.

• Illness requiring overnight hospitalization in the past 6 months

• Active tobacco or recreational drug use

• Pregnancy or current breast feeding