The Relationships Between the Noradrenergic, Opioid and Pain System

• Status: Withdrawn
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined. Pain perception and modulation will be examined before and after administration of Clonidine or placebo together with Naloxone or saline.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Clonidine; Naloxone

Criteria

Inclusion Criteria:

• Healthy volunteers

• Age 18-40

• No chronic disease

Exclusion Criteria:

• Subjects who suffer from chronic pain / pain syndrome

• use of anti-depressant or anti-psychotic drugs

• suffering from cardiovascular disease

• breast feeding