The Relationship Between MDSCs and NK Cells Activity of CHC Patient Treated by DAAs
Status:
Completed
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
Hepatitis C virus (HCV) infection is easy to chronic and can progress to cirrhosis and liver
cancer. Direct-acting antiviral treatment can significantly improve the prognosis of the
disease and the efficacy is seemingly not affected by a variety of viral factors. In
addition, direct-acting antiviral agents therapy may affect the transformation of the immune
cells and ameliorate the host immune status consequently. This study mainly investigated the
relationship between Direct Acting Antiviral Treatment effect and the functional activity of
myeloid-derived suppressor cells (MDSCs) and natural killer cells (NK cells) in Chronic
Hepatitis C.
Phase:
Early Phase 1
Details
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Treatments:
Ledipasvir Ledipasvir, sofosbuvir drug combination Sofosbuvir