The Rate of Embryo Euploidy in Progestin-primed Ovarian Stimulation Cycles
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
The main objective of this non-inferiority randomized controlled trial is to assess the rate
of blastocyst euploidy and the number of euploid blastocysts in women undergoing IVF/ICSI and
treated with PPOS versus conventional ovarian stimulation based on the use of GnRH antagonist
The hypothesis is that PPOS is associated with a rate of blastocyst euploidy similar to what
found with the conventional ovarian stimulation. In other words, the number of euploid
blastocysts that can be obtained with the PPOS strategy is expected to be the same obtained
with conventional ovarian stimulation.
Moreover we expect to find non significant differences in all intermediate outcome of the IVF
cycles, such as in the rate of premature LH surge, in the rate of patients with elevation of
Progesterone on the triggering day, in FSH consumption and length of stimulation, in the rate
of poor response and hyperresponse, in number of retrieved and mature oocytes, in
fertilization and blastulation rate, in the number of available blastocysts and in the
morphological quality of blastocysts