The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma
Status:
Unknown status
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
This study aims to assess the effect of inhaled corticosteroids (ICS) on airway smooth muscle
(ASM) Na+, K+ pumps in patients with asthma.We wish to investigate differences in Na+, K+
pump content in healthy versus asthmatic patients, whether a reduction in airway
hyper-responsiveness observed in asthmatic patients treated with ICS is attributable to an
increase in Na+, K+ pump content in ASM cells and compare this in patients with
non-eosinophilic asthma versus eosinophilic asthma.