Overview

The Protective Effect of Prostaglandin on Coronary Microcirculation and Ventricular Remodeling After Reperfusion Therapy in Acute ST-segment Elevation Myocardial Infarction

Status:
Not yet recruiting
Trial end date:
2022-01-12
Target enrollment:
0
Participant gender:
All
Summary
To explore the protective effect of prostaglandin sodium on coronary microcirculation function and ventricular remodeling after reperfusion treatment of acute ST-segment elevation myocardial infarction.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Shenzhen People's Hospital
Criteria
Inclusion Criteria:

- 1) Meet the diagnostic criteria for acute ST-segment elevation myocardial infarction:
①The onset of ischemic chest pain lasts for more than 30 minutes and cannot be
relieved by taking nitroglycerin; ②The ECG has two or more ST-segment elevations in
adjacent leads , Limb leads ≥ 1mm, pectoral leads ≥ 2mm; or newly-appearing left
bundle branch block; ③The increase in serum markers of myocardial necrosis is at least
twice the normal value; (2) Coronary angiography confirmed acute myocardial
infarction; (3) Direct PCI treatment within 12 hours of onset; (4) Complete clinical
and radiographic data.

Exclusion Criteria:

- (1) Those who do not cooperate in the inspection, have poor compliance, and cannot
guarantee the completion of the test; (2) Persons with consciousness impairment,
obvious intellectual impairment and mental abnormality; (3) With metal foreign bodies,
such as metal prostheses, intraocular metal foreign bodies, intracranial aneurysm
clamps, etc.; (4) Those who suffer from closure phobia; (5) Those who have had a
history of myocardial infarction, PCI treatment, or coronary artery bypass graft; (6)
Factors affecting the changes in the ST segment of the electrocardiogram: complete
left bundle branch block, pre-excitation syndrome, pacemaker electrocardiogram