The Prognostic Impact of Selenium On Critical Surgical Patients

• Status: Recruiting
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement but the dose and results are controversial.

Patients after operations for acute abdomen usually suffer from sepsis and stress. The aim of this study is to investigate the efficacy of selenium replacement in critical patients of acute abdomen, to see the impact on prognosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chang Gung Memorial Hospital
• Treatments: Selenium

Criteria

Inclusion Criteria:

• Intensive care unit (ICU) patients receiving abdominal surgeries for acute abdomen

• within 48 hours post-operatively

• stay in ICU for more than 48 hours

• meets sepsis criteria of Sepsis-3 (2016)

Exclusion Criteria:

• liver cirrhosis Child-Pugh score B or C

• breastfeeding or pregnancy

• allergy yo selenium

• vegetative status or irreversible diseases with life-expectancy fewer than 28 days

• End-stage renal disease under dialysis

• Human inmunodeficiency virus infection

• neutropenia not due to sepsis (granulocyte < 1000/mm3)

• Heart failure (New York Heart Association class III-IV) or recent myocardial infarction (within 6 weeks)

• post cardiopulmonary cerebral resuscitation within 4 weeks

• taking immunosuppressants

• receiving anti-cancer therapy

• signed do not resuscitation

• joined other clinical research