The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Minimally invasive upper tract lithotomy is currently a common operation method on treatment
of urinary tract stones, but the postoperative complication urinary tract infection or
urinary sepsis has turned into a serious threat to the patient's life, when severe, can
result in a higher death rate.Although more the more importance were attached to, an
effective prevention measures still have not been found.
Among Urinary calculi, the higher rates of infection stone resulted in a higher incidence of
postoperative urinary tract infection. The conventional postoperative prophylaxis medicine
was the use of antimicrobial drugs half an hour before surgery.Foreign studies had shown that
continuous preoperative one week use of nitrofurantoin can significantly reduce the incidence
of urinary sepsis. So the investigators assume that preoperative extended use time of
prophylaxis antibiotic may reduce the incidence of urinary tract infection or urinary sepsis.
This study uses a computerized random method. According to preoperative use of different
antimicrobial drug or treatment, all patients are randomly divided into five groups, namely
levofloxacin 3days group,levofloxacin 7days group, nitrofurantoin 3days group,nitrofurantoin
7days group and cefuroxime group.The levofloxacin group receives levofloxacin 0.5g, qd, po,
the nitrofurantoin group was given oral nitrofurantoin 100mg, tid, po.to explore the better
antibiotics types, medication timing and duration of treatment to prevent postoperative
infection after minimally invasive upper tract lithotomy, so as to reduce the incidence of
postoperative urinary tract infection or sepsis.
Phase:
Early Phase 1
Details
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine