The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients

• Status: Unknown status
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effect of normalization of vitamin D levels on bone density, immune and adipocyte function in HIV1-seropositive patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• >18 jr

• able to give informed consent

• HIV seropositive diagnosed with standard techniques

• Hypovitaminoses D

Exclusion Criteria:

• Hypercalcemia: calcium levels >2.60 mmol/L

• Renal disorders: serum creatinine >2 times Upper limit of normal (ULN) (110 mmol/l)

• Liver disorders; elevation of ASAT or ALAT >5 x ULN. The ULNs are 40 IU/L and 45 IU/L for ASAT and ALAT, respectively.

• Pregnancy

• Drug or alcohol abuse

• Non compliance