The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques

• Status: Unknown status
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

• The prediction of extent and risk profile of coronary atherosclerosis based on clinical evaluation and non-invasive techniques.

• Detailed analysis of plaque volume, plaque composition, risk plaque features and shear stress (WSS) changes during lipid lowering therapy (rosuvastatin 40mg) from 3D vessel reconstruction.

• Prediction of changes in coronary arteries based on changes in non-invasive examinations.

• Examination of WSS influence on atherosclerosis development and changes of WSS during lipid lowering therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: General University Hospital, Prague
• Collaborators: Czech Ministry of Education; Loyola University Chicago; Ministry of Health, Czech Republic; University of Iowa
• Treatments: Rosuvastatin Calcium

Criteria

Inclusion Criteria:

• stable angina pectoris

Exclusion Criteria:

• age less than 18 or more than 80

• renal insufficiency

• liver insufficiency

• pregnancy or , child potential without contraception

• intolerance of statins

• rhabdomyolysis or other myopathy in patient´s history

• acute coronary syndrome in last 6 weeks

• coronary anatomy unsuitable for intravascular ultrasound

• active cancer