The PHYSIC study aims to investigate the potential for precision medicine in the treatment of
high blood pressure.
It is a double-blind, randomized, repeated cross-over trial with six treatment periods: four
classes of blood pressure-lowering drugs where treatment with two classes are repeated for
each patient. The classes of blood pressure-lowering drugs to be tested are a diuretic, a
calcium channel blocker, an ACE-inhibitor and an angiotensin receptor blocker.