The Pre-Emptive Administration Of Ketamine for Controlling Post-thoracotomy Pain
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
The goal of this paper is to evaluate whether the pre-emptive administration of Ketamine
would potentiate the effect of intravenous morphine analgesia in management of post
thoracotomy pain. This was a single center, double-blind, placebo controlled, parallel-group,
prospective study. Patients were randomly assigned to receive 1 mg/kg ketamine (Ketamine
Group) or an equivalent dose of normal saline (Placebo Group) before thoracotomy in 1:1
ratio. All patients received postoperatively intravenous morphine administration as
additional analgesic regimen Primary end-point was pain relief measured with Visual Analogue
Scale at rest. The secondary end-points were the reduction of inflammatory response expressed
by plasma c-reactive protein levels, the morphine consumption, and the rate of side effects.
The measurements were carried out 6; 12; 24; 36; and 48 post operative hours.