The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

• Status: Not yet recruiting
• Trial end date: 2025-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Florida
• Treatments: Oxycodone; Oxytocin

Criteria

Inclusion Criteria:

• Individuals fluent in English will participate.

• Must report some experience with opioids (e.g., oxycodone, defined as use at least once in the subject's lifetime).

• Be within 20% of their ideal body weight.

• Are not currently experiencing chronic pain (pain on most days during the past 3 months)

• Have a systolic blood pressure of <=140 and diastolic blood pressure of <= 90, and a heart rate <= 90 beats per minute.

• Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications.

Exclusion Criteria:

• Significant current physical disease or major (uncontrolled) psychiatric disorder.

• No self-reported current interest in drug abuse treatment.

• Women who are pregnant or nursing.

• Any severe comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.