The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

• Status: Active, not recruiting
• Trial end date: 2024-08-08
• Target enrollment: 0
• Participant gender: All

Summary

The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children with Moderate Persistent Asthma

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tanta University
• Treatments: Biotin

Criteria

Inclusion Criteria:

• Children with moderate persistent asthma

• Age range of 8-< 18 years old

• Both sex

Exclusion Criteria:

• Children with any pulmonary or chronic systemic diseases other than asthma (cystic fibrosis, bronchiectasis, tuberculosis, diabetes mellitus, and liver disease).

• Children with immunodeficiency.

• Children with thyroid disorder.

• Children with recent infection (especially pneumonia), surgery, anesthesia.

• Children having clinical evidence of any heart renal and hepatic diseases.

• Children having cystic fibrosis or congenital respiratory disease.

• Children having chronic diarrhea and mal-absorption.

• Children having clinical evidence of malnutrition.

• Children on medications that could interfere with L-carnitine level including antibiotics use. (particularly ampicillins) and anti- convulsing particularly valoproic acid.