The Pharmacokinetics of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5%
Status:
Recruiting
Trial end date:
2022-05-01
Target enrollment:
Participant gender:
Summary
Endophthalmitis is defined as intraocular inflammatory disorder affecting the vitreous cavity
that can result from exogenous or endogenous spread of infecting organisms into the eye.
Patients presents with reduced or blurred vision, red eye, pain, and lid swelling.
Endophthalmitis can progress into panophthalmitis, corneal infiltration and perforation, and
finally phthisis bulbi. For exogenous endopthalmitis, the intraocular inflammation occurs due
to a breach of the ocular compartment. The infectious agent indirectly introduced into the
eye. This usually happens after intraocular surgery such as cataract surgery, vitrectomy,
glaucoma filtration surgery, intravitreal injections, and other causes include penetrating
ocular trauma or from adjacent periocular tissue. Several prophylactic measures have been
taken to reduce the incidence of post-operative endopthalmitis post-cataract surgery, this
includes the use of pre-operative topical levofloxacin, intracameral cefuroxime, and
providone iodine as ocular surface preparation.The proposed study is to evaluate the
pharmacokinetic parameters of Levofloxacin 1.5% vs Moxifloxacin 0.5% aqueous and vitreous
fluid after topical administration on the anterior segment parameters.