The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion
Status:
Completed
Trial end date:
2007-06-01
Target enrollment:
Participant gender:
Summary
There is a need to understand how long anesthetic drugs last in the brain during surgery on
the ascending aorta or aortic arch. Drugs can have a prolonged effect when blood temperature
is made cold therefore the influence of temperature needs to be studied. This type of surgery
allows us to answer questions about how anesthetic drugs behave when they are given during a
routine portion of surgery. Patients will be provided with anesthetic drugs during surgery
while on a heart lung machine. After the drug is injected into the heart lung machine it will
be delivered to the brain to provide more sleep and pain relief. Immediately after the
injection of anesthetic drugs, blood samples will be taken from an existing intravenous line
in the neck and plasma drug concentrations measured. This will help us to understand how long
drugs last in the brain during this type of surgery.
Details
Lead Sponsor:
Columbia University
Treatments:
Analgesics, Opioid Hypnotics and Sedatives Sufentanil