The Pharmacokinetics of Opioids and Sedative/Hypnotics During Selective Cerebral Perfusion

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

There is a need to understand how long anesthetic drugs last in the brain during surgery on the ascending aorta or aortic arch. Drugs can have a prolonged effect when blood temperature is made cold therefore the influence of temperature needs to be studied. This type of surgery allows us to answer questions about how anesthetic drugs behave when they are given during a routine portion of surgery. Patients will be provided with anesthetic drugs during surgery while on a heart lung machine. After the drug is injected into the heart lung machine it will be delivered to the brain to provide more sleep and pain relief. Immediately after the injection of anesthetic drugs, blood samples will be taken from an existing intravenous line in the neck and plasma drug concentrations measured. This will help us to understand how long drugs last in the brain during this type of surgery.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University
• Treatments: Analgesics, Opioid; Hypnotics and Sedatives; Sufentanil

Criteria

Inclusion Criteria:

• The study population will comprise individuals who have elected to undergo aortic arch surgery or re-operative cardiac surgery requiring selective cerebral perfusion.

• Patients will be treated according to the standard medical practice of Columbia University Medical Center.

• Patients will be within 21 to 90 years of age.

Exclusion Criteria:

• Patients having known hypersensitivity to the anesthetic agents being studied will be excluded.