The Optimization of Conditioning Regimen for HLA Matched HSCT in SAA
Status:
Recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
Hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen (HLA) -matched
donor is an effective option for severe aplastic anemia (SAA), but there is no standardized
and recommended conditioning regimen. The occurrence of mixed chimerism after transplantation
is associated with secondary graft failure and poor failure-free survival. Previous studies
have shown that Fludarabine (Flu)/ Cyclophosphamide (Cy)/ antithymocyte globulin
(antithymocyte globulin), ATG) and Cy/ATG conditioning regimens had higher rates of mixed
chimerism and poorer failure-free survival. A small cohort study has suggested that adding
busulfan to Flu/Cy/ATG or Cy/ATG can reduce the incidence of mixed chimerism and improve
failure-free survival. This study was a prospective, multicenter, randomized controlled trial
to compare the efficacy and safety of different conditioning regimens in the treatment of
severe aplastic anemia (SAA) after hematopoietic stem cell transplantation (HSCT) from
HLA-identical sibling or unrelated donor.