The brain protection effect of dexmedetomidine has been approved in several studies.
Basically, the anti-inflammatory effects and reducing catecholamines are thought to be a main
role of the protection effect. In many studies reported the advantage of dexmedetomidine as a
substitution of other sedative drugs for anesthesia.
The anesthesia of intra-cranial aneurysmal clipping operation commonly use intravenous
anesthetic agents combined with inhalation anesthesia for neuroprotection, and mostly
propofol is used.
The aim of this study is to examine the effects of dexmedetomidine on serum inflammatory
markers and research the hemodynamic stability of dexmedetomidine compared to propofol in
aneurysmal clipping operation.