The Myocardial Protective Effects of a Moderate-potassium Blood Cardioplegia in Pediatric Cardiac Surgery
Status:
Completed
Trial end date:
2010-10-01
Target enrollment:
Participant gender:
Summary
The investigators previously investigated the cardioprotective effect of an
adenosine-lidocaine cardioplegia with moderate-potassium (K+, 10.0 mmol/L) in pediatric
cardiac surgery, which was associated with better myocardial protective effects when compared
with conventional high-potassium cardioplegia. However, this cardioplegia could not be sucked
back into the cardiopulmonary bypass (CPB) circuit because of excessive hemodilution and
severe systemic hypotension induced by adenosine. Therefore, the investigators supposed that
a moderate-potassium (K+, 10.0 mmol/L) blood cardioplegia without adenosine could also arrest
the heart and have better myocardial protective effects compared with conventional
hyperkalamic cold blood cardioplegia during cardiac operations without excessive hemodilution
and systemic hypotension.