The Multicenter Atorvastatin Plaque Stabilization (MAPS) Study
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The impact on cardiovascular events achieved by statin therapy seems to be mostly
attributable to the cholesterol-lowering effect with a highly debated contribution of the
lipid-independent pleiotropic effects. However, a short-term benefit has been documented for
patients treated with statins in acute coronary syndromes and other clinical settings. These
observations strengthened the hypothesis of additional, so-called pleiotropic actions of
statins.
The investigators therefore sought to investigate how different lipid-lowering strategies
(non-statin therapy, low-dose statin and high-dose statin) affects cellular composition of
carotid plaque over a short-term period of three months. Specifically the investigators tried
and dissect the LDL-C lowering impact on plaque cellular composition as compared to the
lipid-independent contribution on plaque macrophage and smooth muscle cells.
Phase:
N/A
Details
Lead Sponsor:
University of Padova University of Padua
Collaborators:
Biomedical Foundation for Cardiovascular Research of Padova Pfizer