The goal of the "Mochudi Prevention Project" is to reduce the number of new HIV infections in
the village of Mochudi, Botswana by promoting a comprehensive package of interventions that
have proven to be effective in preventing the spread of HIV. This antiretroviral treatment
(ART) clinical study is nested within the Mochudi Prevention Project, and is being conducted
in the north-east segment (NES) of the village of Mochudi. The ART intervention component of
the Mochudi Project is designed to determine the uptake of, adherence to, and feasibility of
3-drug combination ART as a component of a package of transmission prevention strategies. The
hypotheses are 1) that ART (with 3 antiretrovirals from two classes of drugs) among
participants with CD4 ≥ 250 cells/mm3 and VL ≥ 50,000 cp/mL will be acceptable and safe and
2) Eighty percent of eligible participants will agree to start 3-drug ART.
Phase:
N/A
Details
Lead Sponsor:
Harvard School of Public Health Harvard School of Public Health (HSPH)
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)