The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Treatments: Cyclooxygenase Inhibitors; Diclofenac; Glucuronyl glucosamine glycan sulfate; Nitroglycerin; Ophthalmic Solutions; Tetrahydrozoline

Criteria

Inclusion Criteria:

• Age between >19 and <61 years

• No known systemic or ocular diseases

Exclusion Criteria:

• Cardio-vascular disease

• Lung disease

• Epilepsy

• Previous ocular disease

• Previous treatment with medications influencing the intraocular pressure or the metabolism of nitric oxide or prostaglandins

• Daily intake of medicine except contraceptive pills

• Pregnancy or breastfeeding

• Known allergy against any of the drugs used in the interventions