The Measurement-based Care in Patients With Depressive Disorder: A Randomized Controlled Trial
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
In recent years, measurement-based care (MBC) has been gaining more attention in the
treatment of depression because it allows psychiatrists to individualize treatment decisions
for each patient based on the change of psychopathology and tolerance toward antidepressants.
Several studies, such as the Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
trial using MBC, found that MBC-informed sequential algorithms can be successfully integrated
into clinical practice and improve patients' outcomes However, despite a strong theoretical
rationale for MBC and data supporting the ability to implement MBC in clinical practice
settings, there is currently no randomized controlled trial in MDD patients comparing MBC
with usual/standard care. The investigators compare MBC with clinician's treatment decisions,
standardizing care to two commonly prescribed antidepressants.
Therefore, the aim of this study is to determine the effects of MBC in patients with MDD
compared to standard treatment (ST). The research hypothesis is that compared to ST, the
estimated time to response and to remission would be significantly shorter in the MBC group
without increased dropout rates and side effect burden.