The Link Between Obesity And Vitamin D in Bariatric Patients With Omega-loop Bypass Surgery

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to increase vitamin D concentrations or to keep it on high level, respectively, by supplementing with vitamin D3 in a different dose regime, and to improve the overall health status in bariatric patients. In this project, the vitamin D status, the parameters of inflammation, bone turnover, insulin resistance, liver and depression score of bariatric patients are expected to improve, due to supplementation of a loading dose compared to the standard therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Maria Luger
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Planned omega loop bypass surgery

• 25-hydroxy vitamin D < 75 nmol/l

• BMI >40 or ≥35 kg/m2 with co-morbidities e.g. diabetes mellitus, hypertension

• Body weight <140 kg (due to limitation of DEXA measurement)

• Capability to consent

Exclusion Criteria:

• Another planned form of bariatric surgery

• Hypercalcemia (calcium >2.63 mmol/l) or hypocalcemia (<1.75 mmol/l)

• Renal insufficiency (creatinine >133 μmol/l or GFR <50 ml/min)

• Primary hyperparathyroidism

• Malignancy

• Infection e.g. human immunodeficiency virus

• Medical conditions requiring daily calcium supplements or antacid use

• Known hypersensitivity to cholecalciferol

• No capability to consent

• Imprisoned persons