The Ketamine for Acute Postoperative Analgesia (KAPA) Trial
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Postoperative pain remains an important challenge for both patients and clinicians. Despite
advances in pain management techniques, many patients continue to describe their pain as
moderate to severe immediately after surgery. Poor postoperative pain control is associated
with increased morbidity, functional impairment, and higher health care costs. While opioids
currently represent the mainstay of treating surgical pain, their use is associated with
significant side effects including respiratory depression, delayed recovery of bowel function
as well as the potential for long-term use. Therefore, there is an urgent need to find new
pain relievers with a safer side effect profiles. One such drug that has been receiving
increasing attention is ketamine. Previous studies have focused on using intravenous ketamine
postoperatively which requires a monitored setting but have ignored the oral form. By using
the oral route of administration, ketamine could potentially be used by patients in a less
resource-intensive manner with similar efficacy. Therefore, Investigators propose to conduct
the Ketamine for Acute Postoperative Analgesia (KAPA) pilot study to examine the role of oral
ketamine in improving recovery after spine surgery.
Phase:
Phase 3
Details
Lead Sponsor:
Michael Dinsmore
Collaborators:
MOUNT SINAI HOSPITAL University Health Network, Toronto