The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.

• Status: Recruiting
• Trial end date: 2023-03-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study to investigate whether

• Opening of KATP channels causes migraine pain by activation of meningeal nociceptors and ascending trigeminal nociceptive pathways.

• Opening of KATP channels causes migraine aura by induction of CSD.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Cromakalim

Criteria

Inclusion Criteria:

• Migraine patients

• 18-60 years.

• 50-100 kg.

• Women of childbearing potential must use adequate contraception.

Exclusion Criteria:

• A history of serious somatic disease

• Any other type of headache (except episodic tension-type headache less than once a month) Daily intake of any medication except contraceptives Contraindications for MRI scan.