The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
The major goal of this study is to determine if the innate immune response is dysregulated in
people with fibromyalgia, compared to healthy controls. Magnetic resonance spectroscopy will
be used to measure changes in the brain's metabolic profile following an experimental immune
stimulus, to test whether individuals with fibromyalgia show a heightened immune response in
the brain. The ultimate goal of this research is to better understand the role of brain
inflammation in the pathophysiology of chronic pain and fatigue, which will guide the
development of more effective therapies for these conditions.