The Influence of Phenotype, Grapefruit Juice and Orange Juice on the Pharmacokinetics of Sunitinib in Cancer Patients
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
In this prospective pharmacokinetic we investigate the following topics:
- The influence of grapefruit juice and orange juice on the steady-state pharmacokinetics
of sunitinib in cancer patients
- The influence of sunitinib on the pharmacokinetics of midazolam in cancer patients
- The relationship between Cytochrome-P450-3A4 (CYP3A4) phenotype, as assessed using the
midazolam clearance test, and the steady-state pharmacokinetics of sunitinib in cancer
patients
- The effect of grapefruit juice and orange juice on CYP3A4 metabolism