The Influence of Intravenous Lidocaine on the Action of the Neuromuscular Blocker Rocuronium
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
Lidocaine is a local anesthetic which is widely used in daily anesthesia and surgical
practice. It has been shown that intravenous lidocaine given during an operation has
analgesic properties. Finally intravenous lidocaine is inexpensive and easy to administer and
safe if non-toxic doses are respected. It is likely that the use of lidocaine infusions
during anesthesia might increase in the coming years. Neuromuscular blockers (curare like
substances) are used in anesthesia to facilitate tracheal intubation and to achieve muscle
relaxation and immobility during surgery. Rocuronium is one of the most widely used
neuromuscular blocking agents. Local anesthetics, such as lidocaine, are known to potentiate
the effect of neuromuscular blocking agents. In the study the investigators want to evaluate
the effect of intravenous lidocaine during the operation on the time course of the
rocuronium-induced neuromuscular block. A secondary aim is to evaluate intubation conditions
(lidocaine has been shown also to improve intubation conditions) and safety.