The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals

• Status: Withdrawn
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine the effect of slowing heart rate upon both central and peripheral blood pressures using a medication called Ivabradine which slows heart rate without affecting heart contraction, and to compare the effects of ivabradine to a traditional blood pressure lowering medication called metoprolol (which is a beta-blocker).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bayside Health
• Treatments: Metoprolol

Criteria

Inclusion Criteria:

• Aged 18 - 25 years OR

• Aged > 60 years

Exclusion Criteria

• Chronic disease

• Unable to give informed consent

• Treated or untreated systemic arterial hypertension (SBP > 160 mmHg and/or DBP > 90 mmHg)

• Resting bradycardia (heart rate < 60 beats/minute)

• Pregnancy or active lactation