The Influence of Citric Acid Bone Surface Etching and Bone Defect Fill on GCF BMP-2 Release Profile

• Status: Completed
• Trial end date: 2018-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effect of citric acid on bone surface of infrabony defects when used for 30 seconds at ph 1 and 50% concentration before the application of bovine derived xenograft to fill the defect, Bone Morphogenic protein 2 (BMP-2) marker was evaluated in 5 different days during the first month after surgery and clinical and radiographic parameters were reassessed after 6 months

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Citric Acid; Sodium Citrate

Criteria

Inclusion Criteria:

• Both genders aged between 32-60 years.

• Selected patient with a single site of:

1. Two walled or three walled infra-bony defect.

2. The bone defect should be at least 3 mm in depth from the crest of the alveolar bone to the base of the defect.

3. Pocket depth of more than or equal to 5 mm.

4. Clinical attachment loss equal or more than 3mm

• Patients ready to comply with oral hygiene measures.

Exclusion Criteria:

• Any systemic disease that contra-indicates periodontal surgery or may affect healing.

• Smokers

• Pregnant females

• Drug abusers